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Liposomal Technology · Amitex India

Liposomal
Calcium

An advanced mineral delivery system in which calcium is encapsulated within a phospholipid bilayer vesicle — precisely engineered to protect the active mineral from digestive degradation and release it at the cellular level for significantly improved absorption compared to conventional calcium supplement formats.

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Why Choose Amitex
Unique Selling Propositions
01
The phospholipid bilayer encapsulation actively shields calcium from acidic gastric degradation and enzymatic breakdown in the digestive tract — ensuring the mineral arrives at intestinal absorption sites structurally intact and at full potency rather than being partially neutralised before it can be absorbed.
02
Even at lower supplemental doses, Liposomal Calcium achieves substantially enhanced intestinal absorption — with the liposomal vesicle facilitating transmucosal uptake that operates independently of the saturable transport channels that constrain conventional calcium salt absorption at higher doses.
03
By preventing direct contact between calcium ions and the intestinal mucosa, the lipid encapsulation system eliminates the GI discomfort — including constipation, bloating, and gastric irritation — that frequently limits patient adherence to conventional calcium supplementation regimens.
04
The phosphatidylcholine-based bilayer closely replicates the molecular architecture of biological cell membranes, enabling seamless vesicle-epithelium fusion and direct intracellular calcium delivery — making Liposomal Calcium one of the most physiologically aligned calcium delivery formats available for formulation.
05
Calcium is the most abundant mineral in the human body — governing skeletal mineralisation, neuromuscular signalling, cardiac electrophysiology, and hormonal secretion. The liposomal format ensures these foundational physiological processes are continuously served by a highly bioavailable, well-tolerated calcium source at the cellular level.
06
Manufactured under rigorous GMP-compliant conditions with tightly controlled nanoparticle size distribution (100–220 nm) — ensuring consistent batch-to-batch encapsulation integrity, long-term mineral retention, and full product stability throughout the validated 3-year shelf life.
Physical & Storage Properties
Product Insights
Appearance
Off-white to white, dry free-flowing powder with uniform particle morphology
Solubility
Readily water-dispersible in liposomal form; the phospholipid shell enables aqueous suspendibility without particle agglomeration
Stability
Highly stable under GMP-compliant storage conditions; the phospholipid bilayer protects calcium from moisture-induced degradation and physicochemical deterioration throughout shelf life
Formulation Types
Powder, oral liquid suspension, and capsules
Particle Size
100–220 nm (narrow, tightly controlled size distribution)
pH Range
6.0 – 7.5
Storage Temperature
≤ 20°C, in a cool and dry environment
Storage Conditions
Store in a sealed, airtight container away from direct sunlight, moisture, and sources of heat
Odour
Mild, faintly characteristic odour; essentially odourless in encapsulated powder form
Packaging
Food-grade HDPE drums with inner poly liner; custom pack sizes available on request
Product Overview
Description & Benefits

Liposomal Calcium is a pharmaceutical-grade active ingredient in which calcium is encapsulated within a phospholipid bilayer vesicle structure. As the most abundant mineral in the human body, calcium is indispensable for skeletal integrity, dental health, neuromuscular coordination, cardiac function, hormone secretion, and enzymatic cofactor activity. Despite its critical biological importance, inadequate calcium intake and poor intestinal absorption efficiency remain widespread — a challenge that conventional supplement forms struggle to overcome effectively.

Standard calcium supplements — carbonate, citrate, and phosphate forms — depend primarily on acid-mediated dissolution and passive paracellular absorption in the small intestine. These mechanisms are inherently dose-limited, highly sensitive to gastric pH, and easily disrupted by competing dietary minerals, oxalates, and phytates. The liposomal delivery approach circumvents these barriers by housing calcium within a lipid vesicle that traverses the GI environment intact and delivers the mineral intracellularly through direct membrane fusion — a mechanism independent of the transporter bottlenecks that constrain conventional forms.

The encapsulating phospholipid layer — predominantly phosphatidylcholine — closely replicates the molecular architecture of cell membranes, enabling natural vesicle-to-epithelium fusion and highly compatible intracellular mineral delivery. The finished product presents as an off-white, dry free-flowing powder with excellent aqueous dispersibility and a controlled nanoparticle size of 100–220 nm, delivering consistent performance across all formulation formats and exceptional batch-to-batch reproducibility.

Calcium's physiological roles span bone mineralisation and fracture prevention, muscle contraction and relaxation, nerve impulse transmission, blood coagulation, and parathyroid hormone regulation — making this high-bioavailability liposomal format especially valuable in formulations targeting bone health, osteoporosis prevention, paediatric growth nutrition, women's health, and post-menopausal mineral supplementation.

  • Delivers calcium directly into cells via phospholipid bilayer membrane fusion — completely bypassing the intestinal transporter saturation and acid-dependency that restricts absorption from conventional carbonate, citrate, and phosphate supplement forms.
  • Achieves meaningfully higher circulating calcium concentrations even at lower supplemental doses — ensuring the skeletal, neuromuscular, and enzymatic systems that depend on calcium are continuously and efficiently supported.
  • Substantially better tolerated than conventional calcium forms — lipid encapsulation prevents direct calcium-mucosa interaction, eliminating the constipation, bloating, and GI discomfort that frequently limit compliance with standard supplementation protocols.
  • Highly compatible with multiple dosage formats — powders, capsules, and oral liquid suspensions — making it exceptionally adaptable for pharmaceutical, nutraceutical, paediatric, and clinical wellness product development.
Formulation Applications
Application of Liposomal Calcium

Bone Mineralisation & Structural Strength

Liposomal Calcium plays a foundational role in maintaining skeletal density and structural integrity. Its advanced liposomal delivery system facilitates superior cellular uptake, making it a highly effective active in formulations designed to support bone mineralisation, enhance calcium deposition in bone matrix, and sustain long-term skeletal strength across all age groups.

Dietary Supplement for Calcium Deficiency

Incorporated as a premium active in oral calcium supplements formulated to correct inadequate mineral intake. The liposomal encapsulation system significantly enhances intestinal absorption and bioavailability — delivering a meaningfully more effective solution for daily calcium replenishment compared to conventional supplement forms such as carbonate or citrate.

Osteoporosis Prevention & Treatment

A clinically relevant active ingredient for formulations targeting osteoporosis management and prevention. Liposomal Calcium's superior intracellular delivery helps maintain adequate bone mineral density in post-menopausal women, elderly individuals, and others at elevated fracture risk — supporting long-term skeletal resilience and reducing the rate of age-related trabecular bone loss.

Athletes & Active Individuals

Widely used in sports nutrition products to help athletes and physically active individuals maintain optimal calcium levels under the increased musculoskeletal demands of regular training. Liposomal Calcium supports bone structural integrity under repetitive loading, regulates muscle contraction and relaxation cycles, and aids in recovery — making it an ideal active for performance and active lifestyle formulations.

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